The new Hard Rock sportsbook will allow players aged 21 or over in the state to place bets across a wide range of sports and competitions.
The app also features a selection of promotions, bet types, reward features and customer support.
The launch was made possible after Hard Rock announced a market access agreement with the NNGE in January this year.
The NNGE, a division of the Navajo Nation, the largest federally recognised Native American Nation in the US, operates five gaming and hospitality facilities across Arizona and New Mexico.
“Arizona has a rich sports culture and we’re proud to enter the state with our great partners at Navajo Gaming,” Hard Rock digital executive managing director and chief executive Marlon Goldstein said.
‘We’re excited to debut our new platform, which players of all experience levels will appreciate for its ease of use, unique features and robust gaming options.”
NNGE interim chief executive Brian Parrish added: “The quality and functionality of the mobile platform is outstanding, and we are anticipating great opportunities to cross-market the NNGE with a premiere gaming-hospitality operator and the world-renowned Hard Rock brand.”
The launch comes after players in Arizona bet a record $563.7m (£433.9m/€518.1m) on sports in January.