The two-year deal is effective immediately and will see the stadium renamed as the BlueBet Stadium.
The Panthers currently sit third in the 2021 NRL table, having won their first two games of the new season.
The team finished top of the 2020 NRL, but lot 26-20 to Melbourne Storm in the grand final.
“For a number of years Panthers intentionally retained the naming rights to our home ground,” Panthers chief executive Brian Fletcher said. “However the significant and ongoing financial impact of Covid-19, combined with the considerable investment from BlueBet, made this a fantastic opportunity we simply couldn’t pass up.
“We’re excited to welcome BlueBet to the Panthers family and look forward to giving our members and fans plenty to cheer about at BlueBet Stadium.”
BlueBet founder and executive chairman Michael Sullivan added: “We’re putting our money where our mouth is and backing this team to go all the way as evidenced by our investment in BlueBet Stadium.
“We understand how special the club’s spiritual home is to the Panthers family and we take great pride in having our name and our brand associated with it.”