Smith has served as CFO at Playtech since March 2015 and also been head of investor relations for the gambling tech giant for the past seven and a half years.
However, he will leave the business on 28 November having reached a mutual agreement with Playtech.
Chris McGinnis, who has been deputy of investor relations and strategic analysis at Playtech since November 2018, will replace Smith as CFO and executive director.
McGinnis joined Playtech in June 2017 first serving as head of strategic analysis before going on to his directorial role.
Prior to this, McGinnis spent six and a half years with Temenos, where his roles included head of strategy, head of strategic planning, and associator director for investor relations and business strategy.
McGinnis also had spells working in equity research for BofA Merril Lynch, Stefil Nicolaus and UBS Securities.
“On behalf of the board, I would like to thank Andy for the contribution he has made to Playtech over the past seven years and in particular since taking over as CFO in 2017,” Playtech chairman Brian Mattingley said.
“Andy has played a crucial role at the company, helping to steer the business through the pandemic, including delivering a record half-year performance in H1 2022, and leading the recent successful refinancing of Playtech’s external debt in light of the upcoming bond maturity.
“We wish him all the best in his future endeavours.
“I’m delighted that Chris will be joining the board as CFO. In addition to his deep knowledge of Playtech and the sector he brings a strong set of financial and strategic skills that will be invaluable as the company looks to deliver further growth.
“I am very much looking forward to continuing working with him as we execute against our strategy in the coming years.”
During the first half of the year, Playtech reported revenue of €792.3m, up 73% thanks in part to the success of B2C sports betting brand Snai.